International Workshop
"From Homo sapiens
to Homo sapiens liberatus"

25 May
Conference Hall 221, Bldg. "B"

9:15-9:45 Registration, coffee

Chairmen, G. Blobel*, A. Olovnikov

V.P. Skulachev 9:45-10:00 Introductory remarks
V.P. Skulachev and M.V. Skulachev 10:00-10:45 The present state of the art of the SkQ Megaproject

10:45-11:00 Discussion
B. Cannon 11:00-11:15 Multiplicity of beneficial effects of mitochondrially targeted plastoquinone on ageing phenotype in premature ageing mice with increased mitochondrial DNA mutations

11:15-11:30 Discussion
J. Nedergaard 11:30-11:45 Mitochondrial effects of prolonged treatment of mtDNA mutator mice with SkQ

11:45-12:00 Discussion
12:00-12:30 Coffee break

Chairmen, B. Cannon, V.I. Kapelko

D.B. Zorov 12:30-12:45 Effects of SkQs on oxidative stress-mediated injuries of kidney and brain

12:45-13:00 Discussion
B.V. Chernyak 13:00-13:15 SkQ1 accelerates dermal wound healing in animals

13:15-13:30 Discussion
N.G. Kolosova 13:30-13:45 Effects of SkQ on cataract and retinopathies in OXYS rats

13:45-14:00 Discussion
A.A. Zamyatnin 14:00-14:15 Clinical trials of the SkQ1 drops in treatment of "dry eye"

14:15-14:30 Discussion
14:30-15:45 Lunch

Chairmen, J. Nedergaard, E.I. Rogaev

V.N. Anisimov 15:45-16:00 Effects of SkQ on lifespan and spontaneous carcinogenesis in female mice of three different strains

16:00-16:15 Discussion
F.F. Severin 16:15-16:30 Two mechanisms of antioxidant activity of SkQs

16:30-16:45 Discussion
D.A. Cherepanov 16:45-17:00 Possible role of the Complex III-bound cardiolipin dimer in initiation of mitochondrial lipid peroxidation

17:00-17:15 Discussion
S.A. Nedospasov 17:15-17:30 Unexpected features in mice with mutant cytochrome c

17:30-17:45 Discussion
17:45-18:15 Coffee break
J. Mitteldorf 18:15-18:30 Darwinian Evolution is a Highly Evolved Process

18:30-18:45 Discussion
V. Gorbunova 18:45-19:00 SIRT6 promotes DNA repair under stress by mono-ADP-ribosylating PARP1

19:00-19:15 Discussion

Chairmen, G. Libertini, L. Gavrilov

A. Seluanov 19:15-19:30 Anticancer mechanisms in a longest-lived rodent, the naked mole-rat

19:30-19:45 Discussion
H.S. Saunders 19:45-20:00 Non-senescence in classical evolutionary theory

20:00-20:15 Discussion
20:15 Coffee break

26 May
Conference Hall 221, Bldg. "B"

9:00-9:30 Coffee

Chairmen, C.J. Hauser, S.A. Nedospasov

K. Lewis 9:30-9:45 Examples of prokaryotic genetic programs detrimental to individual cell

9:45-10:00 Discussion
N. Gavrilova 10:00-10:15 Comparative analysis of parameters of human ontogenesis and senescence

10:15-10:30 Discussion
G. Libertini 10:30-10:45 Oxidative damage and aging

10:45-11:00 Discussion
T. Goldsmith 11:00-11:15 Rationale for complex programmed life span regulation in mammals

11:15-11:30 Discussion
11:30-12:00 Coffee break

Chairmen, T. Goldsmith, D. Vinogradov

E.I. Rogaev 12:00-12:15 Brain and aging

12:15-12:30 Discussion
C.J. Hauser 12:30-12:45 Mitochondrial debris including mitochondrial DNA and formyl peptides that appear in the blood after major trauma can induce a syndrome resembling sepsis

12:45-13:00 Discussion
A.G. Ryazanov 13:00-13:15 An enzyme whose inactivation delays aging and increases lifespan

13:15-13:30 Discussion

13:30-14:00 General discussion
14:00-15:00 Lunch
POSTERS 15:00-16:00 N.A. Bocharova et al. , Role of mitochondria in cell senescence-induced death of yeast Saccharomyces cerevisiae
E.K. Fetisova et al. , Induction of multidrug resistance P-glycoprotein inhibits the antiapoptotic action of mitochondria-targeted antioxidant SkQR1
L.A. Gavrilov & N.S. Gavrilova, Demographic Consequences of Defeating Aging
E.N. Grigoryan et al. , The novel antioxidant SkQ1 as an effective protector of rat eye tissues during long-term organotypic cultivation
D.A. Knorre et al. , Sir2-dependent daughter-to-mother transport of the damaged proteins in yeast is necessary to prevent high stress sensitivity of the daughters
G. Libertini, Comparison between two paradigms about aging
G. Libertini, Are C. elegans and D. melanogaster valid animal models for studies on aging?
G. Libertini, Arguments against telomere-telomerase system as general defence against cancer
G. Libertini, A proposal: Project "Homo sapiens liberatus II"!
M. Vyssokikh et al. , Altered content and fatty acid composition in cardiolipin of mitochondria from mtDNA mutator mice
L.S. Yaguzhinsky et al. , The study of uncoupling action mechanism of SkQ?SkQ3 family compounds
M.A. Kozlova & A.Y. Mulkidjanian, The impact of membrane-targeted cations on energy conversion in membrane vesicles from Rb. capsulatus
E.V. Titova et al. , The effect of mitochondria-targeted antioxidants on normal and transformed cells in culture
G.S. Shagieva et al. , The effects of mitochondria-targeted antioxidants on human cervical cancer cells in culture
Chairman, V.P. Skulachev 16:00-17:30 Discussion on initiation of the Homo sapiens liberatus (HSL) movement
G. Blobel* 17:30-17:45 Concluding remarks

19:00-22:00 Banquet at a Moscow river boat (starts near Radisson Royal Hotel, former "Ukraina" Hotel)

* Off sick

Homo Sapiens Liberatus Workshop, Moscow State University, May 2010